GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4372836 | 1 | rs2169751 | chr2:28966758 | TRMT61B | chr2:29072690-29093175:- | -0.29 | -5.03 | 7.45E-7 | Body mass index |
| BLCA | cis | rs10935120 | 1 | rs2177601 | chr3:134245434 | ANAPC13 | chr3:134196547-134204865:- | -0.5 | -7.97 | 1.89E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs2177601 | chr3:134245434 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.09 | 5.33E-5 | Height |
| BLCA | cis | rs2243480 | 1 | rs2177703 | chr7:65391717 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.38 | 1.53E-5 | Diabetic kidney disease |
| BLCA | cis | rs732528 | 1 | rs2187143 | chr18:48371565 | MRO | chr18:48321491-48351754:- | 0.25 | 4.58 | 6.33E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs7655841 | 1 | rs2198042 | chr4:129885499 | C4orf33 | chr4:130014829-130033842:+ | 0.31 | 4.91 | 1.35E-6 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs7528684 | 1 | rs2210913 | chr1:157668993 | FCRL3 | chr1:157646278-157670775:- | 0.29 | 9.3 | 1.06E-18 | Type 1 diabetes autoantibodies |
| BLCA | cis | rs7714584 | 1 | rs2217266 | chr5:150272621 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 5.97 | 5.47E-9 | Crohn's disease |
| BLCA | cis | rs2227564 | 1 | rs2227564 | chr10:75673101 | BMS1P4 | chr10:75458909-75490272:- | -0.33 | -5.36 | 1.42E-7 | Inflammatory bowel disease |
| BLCA | cis | rs9369898 | 1 | rs2229384 | chr6:49425521 | CENPQ | chr6:49431096-49460820:+ | 0.39 | 8.38 | 1.03E-15 | Homocysteine levels |
| BLCA | cis | rs11622475 | 1 | rs2236246 | chr14:104379206 | TDRD9 | chr14:104394817-104519002:+ | -0.34 | -5.64 | 3.36E-8 | Bipolar disorder |
| BLCA | cis | rs11622475 | 1 | rs2236247 | chr14:104378087 | TDRD9 | chr14:104394817-104519002:+ | 0.31 | 5.29 | 2.09E-7 | Bipolar disorder |
| BLCA | cis | rs798766 | 1 | rs2236786 | chr4:1719294 | FAM53A | chr4:1641609-1685854:- | 0.31 | 4.35 | 1.73E-5 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs2239557 | 1 | rs2239557 | chr14:74551970 | LIN52 | chr14:74551656-74667117:+ | 0.35 | 7.97 | 1.8E-14 | Common traits (Other) |
| BLCA | cis | rs7224737 | 1 | rs2240009 | chr17:40283142 | DHX58 | chr17:40253422-40264751:- | -0.25 | -4.56 | 6.82E-6 | Fibrinogen levels |